Synthesis and Structure-Activity Relationship of a New Series of Anti-Juvenile Hormone Agents: Alkyl 4-(2-Benzylhexyloxy)benzoates and Ethyl 4-Substituted Benzoates
نویسندگان
چکیده
منابع مشابه
Ethyl 4–[2–(Substituted Benzyl)hexyloxy]benzoates: Anti–Juvenile Hormone Agents with Juvenile Hormone Activity
We have recently discovered ethyl 4–(2–benzylhexyloxy)benzoate (KF–13) as a novel anti–juvenile hormone (anti–JH) agent (Furuta et al., 2007). This compound induced precocious metamorphosis in larvae of the silkworm, Bombyx mori, a clear sign of JH deficiency, and its activity could be completely counteracted by the simultaneous application of methoprene, a JH agonist. Although KF–13 induced ob...
متن کاملSynthesis and Anti–Juvenile Hormone Activity of Alkyl 4–(2–Phenoxyalkyloxy)benzoates and Related Compounds
Since juvenile hormone (JH) is involved in a wide range of physiological processes in both developing and mature insects (Riddiford, 1994), compounds that possess anti–JH activity are potentially useful not only as biochemical probes to assist in elucidating the role of JH in insect development and reproduction, but also as insect growth regulators (Staal, 1986). Several compounds including pre...
متن کاملSynthesis and anti-juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates.
A series of ethyl 4-(2-aryloxyhexyloxy)benzoates was prepared and tested for their activity to induce precocious metamorphosis in larvae of the silkworm. Phenyl analog 5 showed activity comparable to that of the 6-methyl-3-pyridyl analog reported as a novel anti-JH agent. The activity of 5 could be fully counteracted by methoprene, a JH agonist. The ethoxycarbonyl group of 5 was essential for i...
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Objective(s): Alzheimer's disease (AD) is a neurodegenerative disorder in elderly patients. Decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. Improvement and potentiation of the cholinergic system could be beneficial for treatment of the AD. Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of a...
متن کاملDesign, Synthesis and Anti-Tubercular Activity of Novel 1, 4-Dihydropyrine-3, 5-Dicarboxamide Containing 4(5)-Chloro-2-Ethyl-5(4)-Imidazolyl Moiety
Current researches have showed that N3, N5-diaryl-2, 6-dimethyl -1, 4-dihydropyrine-3, 5- dicarboxamide analogues demonstrate notable anti-tubercular activity. In this study, Hantzsch condensation was used to design and synthesize new analogues of dihydropyridine (DHP). Different diary carboxamides were inserted at positions 3 and 5 of the DHP ring. 4(5)-chloro-2-ethyl-5(4)-imidazolyl moiety wa...
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ژورنال
عنوان ژورنال: Journal of the Faculty of Agriculture, Kyushu University
سال: 2009
ISSN: 0023-6152
DOI: 10.5109/14056